Multiple Sclerosis: Symptoms, Causes and Treatments

 

The multiple sclerosis treatments is a progressive disease of the central nervous system (CNS) characterized by widespread brain injury and spinal cord (Chiaravalloti, Nancy and DeLuca,2008). It is classified within demyelinating diseases of the CNS. These are defined by inadequate formation of myelin or by an impairment of the molecular mechanisms to maintain it (Bermejo-Velasco, et al., 2011).

The clinical and pathological features of multiple sclerosis treatments (MS) were described, in France and later in England, during the second half of the nineteenth century (Compson, 1988).

Multiple sclerosis

However, the earliest anatomical descriptions of multiple sclerosis treatments were made early in the twentieth century (Poser and Brinar, 2003) by Crueilhier and Carswell. It was Charcot who, in 1968, provided the first detailed description of the clinical and evolutionary aspects of the disease (Fernández, 2008).

Multiple Sclerosis Treatments

Although the exact cause of MS is still unknown, it is currently thought to be the result of immunological, genetic and viral factors (Chiaravalloti, Nancy and DeLuca, 2008).

However, the most accepted pathogenic hypothesis is that MS is the result of the conjunction of a certain genetic predisposition and an unknown environmental factor that, when appearing in the same subject, would give rise to a broad spectrum of alterations in the immune response, Would be the cause of the inflammation present in MS lesions. (Fernández, 2000).

Symptoms of multiple sclerosis

MS is a progressive disease with a fluctuating and unpredictable course (Terré-Boliart and Orient-López, 2007), with variability being its most significant clinical feature (Fernández, 2000). This is because the clinical manifestations vary depending on the location of the lesions.

Among the most characteristic symptoms of MS are motor weakness, ataxia , spasticity , optic neuritis, diplopia, pain, fatigue, sphincter incontinence, sexual disorders and dysarthria.

However, these are not the only symptoms that can be observed in the disease, as epileptic seizures, aphasia, hemianopsia and dysphagia may also occur (Junqué and Barroso, 2001).

If we refer to statistical data, we can point out that, motor type alterations are 90-95% the most frequent, followed by sensory alterations in 77% and cerebellar ones in 75% (Carretero-Ares et al. , 2001).

Since the 1980s research has indicated that cognitive impairment is also related to MS (Chiaravalloti, Nancy and DeLuca, 2008). Some studies show that these alterations can be found in up to 65% of patients (Rao, 2004).

Thus, the most common deficits in MS affect information evocation, working memory, abstract and conceptual reasoning, information processing speed, sustained attention, and visuospatial skills (Peyser et al., 1990; Santiago-Rolanía et al., 2006).

On the other hand, Chiaravalloti and DeLuca (2008) point out that although most studies indicate that general intelligence remains intact in patients with MS, other investigations have detected slight but significant decreases.

Histopathology of Multiple Sclerosis

The pathological anatomy of MS is characterized by the appearance of focal lesions on the white matter , called plaques, characterized by loss of myelin (demyelination) and relative preservation of axons, since a variable degree of axonal destruction is always present Fernández, 2000).

These demyelination plaques are of two types depending on the activity of the disease on the one hand, are the plaques on which the acute lesion is recognized, the fundamental pathological phenomenon is inflammation and on the other hand plaques in which a Chronic injury, a product of progressive demyelination (Carretero-Ares et al., 2001).

Regarding their location, they are selectively distributed throughout the CNS , with the most affected regions being the periventricular regions of the brain , nerve II, the optic chiasm , the corpus callosum , the brainstem, the floor of the fourth ventricle, and the pyramidal pathway (García-Lucas, 2004). Plaques may also appear on the gray matter, usually subpinal, but are more difficult to identify; The neurons are usually respected (Fernández, 2000).

The accumulation of axonal loss can cause irreversible damage to the CNS and neurological incapacity (Lassmann, Bruck, Luchhinnetti, & Rodríguez, 1997; Lucchinetti et al. 1996; Trapp et al., 1998).

Epidemiology

Epidemiological investigations have shown that MS is the most common chronic neurological disease in young adults in Europe and North America (Fernández, 2000), with the majority of diagnoses being diagnosed. Cases between the 20 and 40 years of age (Simone, Carrara, Torrorella, Ceccrelli and Livrea, 2000).

The incidence and prevalence of MS in the world has increased at the expense of women, but this is not due to a decline in incidence and prevalence in men, which has remained stable since 1950-2000. The prevalence of the disease in our country ranges from 50-60 cases per 1000 inhabitants (Fernández, 1990).

Clinical course

Studies on the natural evolution of the disease have shown that in 80-85% of patients, the disease starts with outbreaks (De Andrés, 2003). These outbreaks according to the definition of Poser, can be considered as the appearance of symptoms of neurological dysfunction for another 24 hours and that also, as they are repeated, are leaving sequel.

Forms of clinical evolution

According to the US National Multiple Sclerosis Society (NMSS) advisory committee for MS clinical trials , four clinical courses of the disease can be distinguished ( Figure 1 ): recurrent-remitting ( EMRR ), primary progressive ( PFMS ), progressive secondary (PMSCs) and, finally , recurrent-recurrent (PRMS).

multiple sclerosis treatments

Chiaravalloti and DeLuca (2008), define recurrent-remitting MS characterized by periods in which symptoms worsen (period of acute worsening, also called exacerbation, outbreak, or recurrence), although recovery of the outbreaks is observed. About 80% of people with RRMS develop secondary progressive MS later .

In this type of MS, symptoms gradually worsen with or  without occasional relapses, or minor remissions. Recurrent progressive MS is characterized by a progressive worsening after the onset of the disease, with some acute periods. Finally,  progressive primary or chronic progressive MS has a continuous and gradual worsening of symptoms without exacerbation or remission of symptoms.

Diagnosis

For its diagnosis, the diagnostic criteria described by Charcot , based on anatomopathological descriptions of the disease, were initially used. However, these have now been replaced by the criteria described by McDonald in 2001 and revised in 2005.

McDonald’s criteria are based primarily on clinical practice but incorporate magnetic resonance imaging (MRI) in a prominent place , allowing the establishment of spatial and temporal dissemination and, therefore, an earlier diagnosis (ad hoc committee of the group of diseases Demyelinating agents, 2007).

The diagnosis of MS is made taking into account the existence of clinical criteria for spatial dissemination (presence of symptoms and signs indicating the existence of two independent lesions in the CNS) and temporal dispersion (two more episodes of neurological dysfunction), Fernández, 2000).

In addition to the diagnostic criteria, the integration of clinical history information, neurological examination and complementary tests is required to rule out differential diagnoses of MS and to demonstrate the findings that are characteristic of the cerebrospinal fluid (intrathecal secretion Of immunoglobulins with oligoclonal profile) and magnetic resonance imaging (MRI) (Ad-hoc Committee of the group of demyelinating diseases, 2007).

Treatment

Terré-Boliart and Orient-López, 2007). In general, the therapeutic objectives of this disease will be to improve acute episodes, slow disease progression (through immunomodulatory and unimpressive drugs) and treat symptoms and complications.

Due to the symptomatic complexity that these patients may present, the most appropriate treatment framework will be within an interdisciplinary team  (Terré-Boliart and Orient-López, 2007).

Cognitive Function in MS

Memory

Starting with the memory , it considers that this is one of the most sensitive brain damage neuropsychological functions and therefore one of the most evaluated in people with MS (Tinnefeld, Treitz, Haasse, Whilhem, Daum and Faustmann, 2005; Arango-Laspirilla et al., 2007).

As indicated by numerous studies, memory deficit seems to be one of the most frequent disorders associated with this pathology (Armstrong et al., 1996; Rao, 1986; Introzzini et al., 2010). Such deterioration usually compromises long-term episodic memory and working memory (Drake, Carrá and Allegri, 2001). However, it seems that not all components of memory would be affected, since semantic memory, implied memory and  short-term memory seem unaffected.

On the other hand it is also possible to find alterations in the visual memory of patients with MS as the results obtained in the studies of Klonoff et al, 1991; Landro et al, 2000; Ruegggieri et al, 2003; And Santiago, Guardiola and Arbizu, 2006.

Early work on memory impairment in MS suggested that difficulty in long-term storage recovery was the main cause of memory deficit (Chiaravalloti and DeLuca, 2008).

Many authors believe that memory disorder in MS derives from a difficulty in “retrieving” information rather than a storage deficit (DeLuca et al., 1994; Landette and Casanova, 2001). More recently, however, research has shown that the primary memory problem lies in the initial learning of information.

Patients with MS require more repetition of information to reach a predetermined learning criterion, but once information has been acquired, recall and recognition reach the same level as healthy controls (Chiaravalloti and DeLuca, 2008, Mataró and Pueyo, 2013).

The deficit in the realization of new learning causes mistakes in the decision making and seems to affect the potential capacities of memory. Several factors have been associated with low learning ability in people with MS, such as processing speed impaired, susceptibility to interference, executive dysfunction and perceptual deficits. (Chiaravalloti and DeLuca, 2008, Jurado, Mataró and Pueyo, 2013).

Information Processing

Efficiency in information processing refers to the ability to maintain and manipulate information in the brain for a short period of time (working memory) and the speed with which that information can be processed (processing speed) .

The reduced rate of information processing is the most common cognitive deficit in MS. These deficits in processing speed are seen in conjunction with other cognitive deficits that are common in MS, such as deficits in working memory and long-term memory.

The results of  recent studies with large samples have shown that people with MS have a significantly higher incidence of processing speed deficits rather than working memory, particularly in patients with a progressive secondary course.

Attention

According to Plohmann et al. (1998) attention is possibly the most prominent aspect of cognitive impairment in some MS patients, thus it is usually one of the first neuropsychological manifestations in people with MS (Festein, 2004; Arango-Laspirilla, DeLuca and Chiaravalloti, 2007 ).

In this paper we present the results of a series of tests that evaluate both sustained and divided attention (Arango-Laspirilla, DeLuca and Chiaravalloti, 2007).

Typically, basic care tasks (eg, digit repetition) are not affected in MS patients. The deterioration in sustained attention is more common and specific affections have been described in divided attention (that is, tasks that could be done to patients who attend to various tasks) (Chiaravalloti and DeLuca, 2008)

Executive functions

There is empirical evidence that a high proportion of MS patients present alterations in their executive functions (Arnett, Rao, Grafman, Bernardin, Luchetta et al., 1997; Beatty, Goodkin, Beatty and Monson, 1989) In the frontal lobe , caused by the processes of demyelination, may lead to a deficit of executive functions such as reasoning, conceptualization, task planning or problem solving (Introzzi, Urquijo, López-Ramón, 2010)

Visoperceptive Functions

Difficulties in visual processing in MS can have a detrimental effect on visoperceptive processing, although perceptual  deficits are independent of primary visual disturbances. The visoperceptive functions not only include the recognition of a visual stimulus  , but also the ability to perceive the characteristics of this stimulus with precision.

Although up to a quarter of people with MS may have a deficit in visual perceptual functions, few works have been done on  the processing of visual perception.

Evaluation

The first phase of managing cognitive difficulties involves evaluation. The evaluation of cognitive function requires several neuropsychological tests focused on specific fields such as memory , attention and processing speed (Brochet, 2013).

Usually, cognitive impairment is evaluated by neuropsychological tests, which have shown that this deterioration in MS patients is already present in early stages of this disease (Vázquez-Marrufo, González-Rosa, Vaquero-Casares, Duque, Borgues and Izquierdo , 2009).

Cognitive rehabilitation

Currently, there are no effective pharmacological treatments for cognitive impairment related to MS. In response, other types of treatments, non-pharmacological treatments, among which we find cognitive rehabilitation , whose ultimate goal is to improve cognitive function through practice, exercise, compensation strategies and adaptation to maximize the use of Residual cognitive function (Amato and Goretti, 2013).

Rehabilitation is a complex intervention that poses many challenges for traditional research designs. Unlike a simple pharmacological intervention, rehabilitation includes a variety of different components.

Few studies have been done on the treatment of cognitive deficits and several authors have highlighted the need for additional neuropsychological techniques effective in the rehabilitation of MS. The few cognitive rehabilitation programs for MS aim to improve attentional deficits, communication capacity and memory impairments. (Chiaravalloti and De Luca, 2008).

To date, the results obtained in the cognitive rehabilitation of patients with MS are contradictory. Thus, while some researchers have not seen an improvement in cognitive function, other authors, such as Plowman et al. They claim to have demonstrated the efficacy of some cognitive rehabilitation techniques (Cacho, Gamazo, Fernández-Calvo and Rodríguez-Rodríguez, 2006).

In a comprehensive evidence-based review of available data on the use of cognitive rehabilitation in MS patients, O’Brien and colleagues concluded that, while this research is still in its infancy, there have been Some well-designed studies that can provide a basis from which to  advance in the field (Chiaravalloti and De Luca, 2008).

The rehabilitation program will focus on the consequences of illness rather than on medical diagnosis and the fundamental objective will be to prevent and reduce disability and disability, although at times they can also eliminate deficits (Cobble, Grigsb and Kennedy 1993; , 2002; Terré-Boliart and Orient-López, 2007).

It should be individualized and integrated into an interdisciplinary team, so therapeutic interventions must be performed on different occasions with different objectives given the evolution of this pathology (Asien, Sevilla, Fox, 1996; Terré-Boliart and Orient-López, 2007).

In addition to other therapeutic alternatives available in MS (such as inmonomodular and symptomatic treatments), neurorehabilitation should be considered an intervention that complements the rest and which is oriented to the better quality of life of the patients and their family group (Cárceres, 2000 )

The realization of a rehabilitative treatment may lead to an improvement in some quality of life indices both in the physical health-physical and general health-as well as in the mental health-social function, emotional role and mental health- ( Delgado-Mendilívar, et al., 2005) this may be key since most patients with this disease will live more than half of their lives with it (Hernández, 2000).

Cognitive rehabilitation can bring considerable benefits to people with MS, although research in this field is still too limited to draw definitive conclusions about optimal approaches and strategies (Amato and Goretti, 2013).

Demonstrating the effectiveness of rehabilitation in a heterogeneous progressive pathology such as MS is complex, so it is necessary to carry out more  studies with better design and evaluation scales, which will allow us to better assess what we do and, ultimately, to contribute To improve the treatment we can offer our patients (Terré-Boliart and Orient-López, 2007).

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